Three U.S. service members have been killed in action during combat operations against Iran, U.S. Central Command officials announced Sunday.
Five more have been listed as “seriously wounded,” a harsh reminder that the conflict continues to unfold in real time.
Several other troops “sustained minor shrapnel injuries and concussions — and are in the process of being returned to duty,” the CENTCOM release noted.
The numbers are still evolving as commanders work to stabilize wounded personnel and maintain readiness across a changing battlefield.
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A barrage of Iranian retaliatory strikes were launched at U.S. military installations across the Middle East on Saturday on the heels of a U.S. and Israeli air, land and sea bombardment on the Islamic Republic — a campaign dubbed Operation Epic Fury.
That label reflects a calculated effort to degrade Tehran’s ability to threaten American troops and regional partners.
Initial reports on Saturday indicated there were no U.S. casualties. But officials cautioned that the situation could change as battles continued to unfold and more information became available.

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“Major combat operations continue and our response effort is ongoing,” the CENTCOM statement read.
The message signals a steady, ongoing campaign rather than a one night of heavy blows, and it frames American action as disciplined and deliberate.
The assault by U.S. and partner forces began Saturday at 1:15 a.m., CENTCOM officials stated, with the goal of knocking out “the Iranian regime’s security apparatus, prioritizing locations that posed an imminent threat.” By targeting these facilities, the operation aims to prevent further Iranian strikes and demonstrate resolve to regional adversaries.
Among the primary targets of the operation were Islamic Revolutionary Guard Corps command and control facilities, Iranian air defense capabilities, missile and drone launch sites and military airfields, according to the statement.
The list underscores a broad, coordinated effort designed to erode Tehran’s military capacity and reassure allies watching the region closely.
The compound of Iran’s Supreme Leader Ayatollah Ali Khamenei was also targeted in the operation. A senior Israeli official told Reuters that Khamenei was killed in the strike. President Donald Trump later confirmed in a Truth Social post on Saturday that Khamenei was killed in the attack, calling the moment “the single greatest chance for the Iranian people to take back their Country.”
At least 201 people have been killed and more than 700 injured across Iran, according to the Iranian Red Crescent Society.
Such figures, disputed by Tehran, intensify the humanitarian dimension of the confrontation and intensify calls for clear, decisive American leadership.
The identities of U.S. service members killed in action are being withheld until 24 hours after next of kin notification, officials said. In Washington, a broader debate continues over how to sustain momentum while protecting families and preserving long term strategic interests.
This is a developing story.
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